Douglas L. Black, Ph.D.

dougb at microbio.ucla.edu

 

Professor, Department of Microbiology, Immunology & Molecular Genetics
UCLA and The David Geffen School of Medicine

Member:
UCLA Graduate Program in the Biosciences
    Biochemistry, Biophysics, and Structural Biology Home Area
    Gene Regulation Home Area
UCLA Molecular Biology Institute,
Brain Research Institute,
Jonsson Comprehensive Cancer Center
Affiliate: UCLA Graduate Program in Bioengineering
 

Dr. Black is a Professor in the Department of Microbiology, Immunology, and Molecular Genetics at the University of California, Los Angeles, and the David Geffen School of Medicine at UCLA. His B.A. degree is in chemistry from the University of California, Santa Cruz. He received his Ph.D. degree in molecular biochemistry and biophysics at Yale University, working with Joan Steitz. Prior to his appointment at UCLA, he worked with David Baltimore, Donald Rio, and Phil Sharp at the Whitehead Institute for Biomedical Research and MIT.

Xinyuan Chen

xinyuan at ucla.edu

Xinyuan is currently interested in using high-throughput screening to identify potential splicing regulators in Myc-driven prostate cancer.  

Andrey Damianov

damianov at ucla.edu

Nivedita Damodaren

damo at g.ucla.edu

Nivi is working on understanding the mechanism of RNA-chromatin interactions in mouse embryonic stem cells. 

Reem Halabi

Staff Research Associate

rhalabi at g.ucla.edu

 

Reem is using ribosome profiling to help create a library of biomarkers for CAR-T cell therapy of glioblastoma and to investigate transcript regulation by Rbfox1 in neurons.

Jeffrey Huang

Hanyoung Lim

Hanyoung is currently studying the effects of splicing regulators such as PTBP1 on chromatin retention of pre-mRNAs in mouse embryonic stem cells. His project could provide insight into the complex mechanism behind pre-mRNA quality control. 

Chia-Ho Lin

Bioinformatics Analyst

chiaholi at ucla.edu

Nazim Mohammad

nazim30 at g.ucla.edu

Nazim is interested in deciphering the biological roles of splicing factors on neuronal development and function. His project aims to understand the potential role of splicing regulatory proteins PTBP1 and PTBP2 on the dynamic modification of chromatin architecture, that ultimately controls gene expression.

Julia Nikolic

Lab Manager

julian at microbio.ucla.edu

Xiaojun Wang

wxj406 at gmail.com

Xiaojun focuses on a complex of RNA-binding proteins called the Large Assembly of Splicing Regulators, LASR, and its interactions with the splicing regulators of the Rbfox family. She expresses and purifies recombinant proteins of LASR, tests the interactions between the protein components in vitro, and further determines protein regions/domains that are involved in specific interactions. She also uses Cryo EM, X-ray crystallography and NMR to determine the structures of the LASR complex or its sub-complexes. 

Wen Xiao

Wen is currently interested in identifying Myc-driven alternatively spliced exons in prostate cancer. He will combine high throughput sequencing with a fluorescence reporter system to determine splicing factors and inhibitors of Myc-dependent exons. This project aims to explore the splicing mechanism of Myc-driven tumorigenesis and develop immunotherapeutics against Myc-driven,cancer-specific isoforms.

Kyu-Hyeon Yeom

kyeom at microbio.ucla.edu

Kay is interested in the mechanisms of controlling microRNA expression during neuronal development and the role of this regulation in developmental diseases.