Our Research

Genetic Regulation at the RNA Level.

We are a group of scientists at UCLA studying the fascinating biology of RNA. We are interested in how cells process genetic information to form the messenger RNAs (mRNAs) that encode proteins, and our primary focus is the regulation of the pre-mRNA splicing reaction. In producing multiple mRNAs and proteins from a single DNA gene, alternative splicing is a key mechanism for creating the specialized functions of cells. This mode of gene regulation is particularly prevalent in the mammalian nervous system, where it contributes to the enormous diversity of neuronal cells. Errors in RNA splicing and its regulation also contribute to many aspects of human disease, including cancer, neurodegeneration, and inherited genetic disorders. In studying a variety of biological systems and applying a wide range of molecular approaches, our common goal is to develop a mechanistic understanding of gene regulation at the RNA level, and ultimately apply this knowledge to human health.

Lab News

Congratulations to Kay Yeom and Zhicheng Pan on publishing their intron retention paper as the cover story of the June Issue of Genome Research.

Jun 01, 2021

Check out the beautiful cover picture depicting RNA sequencing data rendered in the Korean style of painting: painting.https://genome.cshlp.org/content/31/6.cover-expansion

Congratulations to Kay on her new job at Amgen. Missing you already… Good luck!

Now up on BioRxiv, Kay Yeom and Zicheng Pan’s paper describes a new framework for retained intron analysis and a novel mechanism for developmental gene regulation. Thanks to Beverly Lin and everyone in the Black and Xing labs for helping bring this long project to completion!

Oct 24, 2020

Check it out on BioRvix! Tracking pre-mRNA maturation across subcellular compartments identifies developmental gene regulation through intron retention and nuclear anchoring. https://biorxiv.org/cgi/content/short/2020.10.23.352088v1

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