Our Research

Genetic Regulation at the RNA Level.

We are a group of scientists at UCLA studying the fascinating biology of RNA. We are interested in how cells process genetic information to form the messenger RNAs (mRNAs) that encode proteins, and our primary focus is the regulation of the pre-mRNA splicing reaction. In producing multiple mRNAs and proteins from a single DNA gene, alternative splicing is a key mechanism for creating the specialized functions of cells. This mode of gene regulation is particularly prevalent in the mammalian nervous system, where it contributes to the enormous diversity of neuronal cells. Errors in RNA splicing and its regulation also contribute to many aspects of human disease, including cancer, neurodegeneration, and inherited genetic disorders. In studying a variety of biological systems and applying a wide range of molecular approaches, our common goal is to develop a mechanistic understanding of gene regulation at the RNA level, and ultimately apply this knowledge to human health.

Lab News

Welcome to the new undergraduate students: Lin Zhou, Sofia Litchev, Kelechi Onwuzurike.

Sep 15, 2021

Congratulations Andrey for receiving seed funding from the Jonsson Comprehensive Cancer Center to develop new assays for studying the interactions of the U2 snRNP with branchpoints. Thank you JCCC!

Aug 17, 2021

The Black and Plath labs have received a research award from the Broad Stem Cell Research Center to study to association of repetitive RNA with chromatin. Thank you BSCRC!

Aug 10, 2021

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