Our Research

Genetic Regulation at the RNA Level.

We are a group of scientists at UCLA studying the fascinating biology of RNA. We are interested in how cells process genetic information to form the messenger RNAs (mRNAs) that encode proteins, and our primary focus is the regulation of the pre-mRNA splicing reaction. In producing multiple mRNAs and proteins from a single DNA gene, alternative splicing is a key mechanism for creating the specialized functions of cells. This mode of gene regulation is particularly prevalent in the mammalian nervous system, where it contributes to the enormous diversity of neuronal cells. Errors in RNA splicing and its regulation also contribute to many aspects of human disease, including cancer, neurodegeneration, and inherited genetic disorders. In studying a variety of biological systems and applying a wide range of molecular approaches, our common goal is to develop a mechanistic understanding of gene regulation at the RNA level, and ultimately apply this knowledge to human health.

Lab News

Congratulations to Daniel for his appointment to the 2022-23 Cell and Molecular Biology (CMB) Training Program. Good job, Daniel!

Jun 21, 2022

Black Lab members attend the 2022 RNA Society meeting in Boulder. Nice seeing old friends and meeting some new ones.

Jun 09, 2022

Congratulations to Nazim for a fantastic talk at the meeting and Xinyuan for winning the poster award!

Congratulations to Xinyuan for receiving the 2021-22 John W. Phillips Legacy Award from the department of MIMG. This award honors the life, work and principles of our beloved collaborator, Dr. John W. Phillips. Thank you MIMG and the Phillips family!

May 28, 2022

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