Our Research

Genetic Regulation at the RNA Level.

We are a group of scientists at UCLA studying the fascinating biology of RNA. We are interested in how cells process genetic information to form the messenger RNAs (mRNAs) that encode proteins, and our primary focus is the regulation of the pre-mRNA splicing reaction. In producing multiple mRNAs and proteins from a single DNA gene, alternative splicing is a key mechanism for creating the specialized functions of cells. This mode of gene regulation is particularly prevalent in the mammalian nervous system, where it contributes to the enormous diversity of neuronal cells. Errors in RNA splicing and its regulation also contribute to many aspects of human disease, including cancer, neurodegeneration, and inherited genetic disorders. In studying a variety of biological systems and applying a wide range of molecular approaches, our common goal is to develop a mechanistic understanding of gene regulation at the RNA level, and ultimately apply this knowledge to human health.

Lab News

Congratulations to Hanyoung for receiving the 2022 Mitsuo Takasugi Award from MIMG department. This award will support Hanyoung to attend the 2022 RNA society meeting in Boulder, Colorado!

May 16, 2022

Congratulations to Parham for receiving a F30 fellowship from National Institute of Mental Health to study how Rbfox and its cofactors in the LASR protein complex regulate alternative splicing in neurons. Thank you NIMH!

May 10, 2022

Congratulations to Parham for passing his oral qualifying exam. Good job, Parham!

Apr 29, 2022

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